Increasing Levels of Free Thyroxine as a Risk Factor for a First Venous Thrombosis: A Case Control Study
(Written by, Lolly, Graves Disease/TED)
I came across this article today after researching something else and found it very interesting especially as, I have gone through something myself very, similar.
Let me give you a little back ground, back in 2003 I started to have slight chest pains thought nothing of it, throughout that evening the pain radiated down my arm but still I thought maybe it was my neck because I have had similar pains associated with cervical spondlyosis.
Well that evening things got worse, but me being the stubborn person I, am still didn’t do anything about it, now my fingers were getting, painful and I didn’t realise they were, getting extremely cold. I took some pain killers and went to bed could I sleep no, the pain was just unbearable. I didn’t want to disturb anyone so I got up made myself a hot drink trying to warm my fingers up this didn’t work it was nearly morning and I’d had enough. I told my family that I was going to the doctors they felt my hand and said you need to go to emergency you fingers are freezing cold. So I did, I was on my own so the nurse who took, my history and checked my left hand and finger, moved me into, the resuscitation room, all systems go, she suspected either an air, embolism or arterial thrombosis not very common having it in the hand.
They sent, straight away for the vascular doctor who bought all his students around great now i was on show because this had never been seen in this hospital only one case many years ago. Most of them guessed I had Reynaud’s but they got it wrong I indeed had an arterial thrombosis in my hand which was cutting of the blood supply to four of my fingers left hand if they didn’t act quickly then chances are I would lose all four of my fingers. I was prepped ready to go down to the x-ray department after blood test results confirmed, I had a thrombosis. They were to do the procedure in there, a great Japanese doctor so nice and all the X-ray staff and theatre nurses to assist they had to make a cut in the femoral Artery and put in a a femoral line flushing out the artery it went from my right side (groin), passing through the Artery right the way down to my left elbow. Then drug busting drugs were put through the line via drip. All the time they were doing this procedure they were taking pictures and had my hand on full view for even me to see it looked like Spaghetti Junction( big major road in Birmingham UK), . I was awake through the whole thing trying to keep a brave face when deep down I was scared to death.
Once the procedure was done I was then transported up to ITU, (intensive care unit)hooked to everything, heart monitor Femoral line drips no part of me was free and in some ways I wish I had been unconscious spent a night of not being able to move. then my left hand went into spasm they called for the doctor who took bloods to check potassium. they weren’t happy that the clots were going so I had to, the have the procedure( angioplasty), done the next day this time going farther down into my hand and spent yet another uncomfortable night on ITU. I was then transported to the ward after femoral line was removed and had to stay in for a further 13 days because my blood just wasn’t getting to a safe level, heparin warfarin bloods taken every few hours my fingers were still painful but now the ends were sloughing and either they were going to drop off or slough and regenerate thank god it was the latter I still get cold fingers to this day middle finger being the coldest. I don’t have all the nerve sensation back fully but better than no fingers at all. While I was still in hospital they wanted me to see a top Heart specialist who came up especially from London to review my case. He asked me lots of questions and some i found rather bizarre and stayed with me a long time. One was have I or do I have cancer have I ever had an abortion well the answer to both those questions was no although now I was wondering do I have cancer. they reason he asked because I wanted to know is this is his word my body was truing on itself and they had done antibodies test which showed specific antibodies associated with someone who had either cancer or an abortion WTF…
Now I guess you are wondering why any of this has to do with thyroid disease Graves disease. Well two years later I was finally diagnosed with Graves disease. I did have a condition called antiphospholipid syndrome (Hughes disease) which is now being managed by blood thinners Clopidgrel after a long time on warfarin therapy, I was also tested for Lupus (negative), had MRI scans of my neck.
My theory has always been that I was already displaying antibodies associated with thyroid disease they just hadn’t picked up on it because the thrombosis had masked it. After reading that article today i wonder how many other, people are at risk from either a stroke DVT or something, much more serious. I was lucky had I not acted any quicker than i did and I wasn’t that quick I may not have been here to tell the tale.
I have known a few people over the years who have had mild strokes associated with thyroid or DVT’s that is why it’s important to get all 3 tests Free T4, Free T3 and TSH.
I hope someone out there is reading this and knows exactly what I mean because they may have been through similar themselves.
Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study
There is a hypercoagulable state in hyperthyroidism, but the association with venous thrombosis (VT) is not fully explored. We aimed to investigate VT risk for different plasma levels of thyroid hormones and thyroid antibodies. We used a case-control study on leg vein thrombosis conducted between September 1999 and August 2006 at the Academic Medical Center, Amsterdam, the Netherlands. Parameters of thyroid function were assessed in 190 cases (mean age 57 years, range 19-90) and 379 sex-matched controls (mean age 56 years, range 18-93). Odds ratios (ORs) and 95% confidence intervals (CI) for VT risk were estimated according to several cut-off levels derived from plasma levels observed in controls. We found the risk of venous thrombosis to gradually rise with increasing levels of free thyroxine (FT4). In the absence of traditional acquired risk factors, FT4 levels above 17 pmol/L yielded a sex- and age-adjusted OR of 2.2 (95%CI 1.2-4.2) for deep venous thrombosis, which further increased up to an OR of 13.0 (95% CI 1.1-154.1) for FT4 levels above reference range. Our data suggest increasing levels of free thyroxine to be a risk factor for venous thrombosis, and may have implications for both the prevention and management of this disease.
Aside: Please continue supporting, Dr. Sarah Myhill, to end the witch hunt for this fine doctor in the UK.
Tags: graves disease affects, graves disease symptoms, Graves' disease patient, Increasing Levels of Free Thyroxine as a Risk Factor for a First Venous Thrombosis: A Case Control Study, TED patient, written by Lolly